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Related Experiment Videos

Gene expression in acute Stanford type A dissection: a comparative microarray study.

Barbara Theresia Weis-Müller1, Olga Modlich, Irina Drobinskaya

  • 1Department of Vascular Surgery and Kidney Transplantation, Heinrich-Heine-University of Düsseldorf, Düsseldorf, Germany. MuellerB@med.uni-duesseldorf.de

Journal of Translational Medicine
|July 11, 2006
PubMed
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Gene expression in aortic dissection reveals down-regulation of structural genes and up-regulation of inflammatory genes, indicating pre-existing aortic wall weakness. This molecular complexity highlights potential causes of aortic dissection.

Area of Science:

  • Cardiovascular Biology
  • Molecular Biology
  • Genomics

Background:

  • Aortic dissection involves complex molecular changes.
  • Gene expression profiles in dissected aorta differ from normal aorta.

Purpose of the Study:

  • To compare gene expression profiles in acutely dissected aorta with normal control aorta.
  • To identify molecular mechanisms underlying aortic dissection.

Main Methods:

  • Gene expression profiling using BD Atlas and Affymetrix GeneChip arrays.
  • Quantitative real-time polymerase chain reaction (RT-PCR) for validation.
  • Analysis focused on genes with strong expression signals.

Main Results:

  • Down-regulation of extracellular matrix genes (collagens, elastin) and myofibrillar genes.

Related Experiment Videos

  • Increased expression of matrix metalloproteinases and inflammatory genes (interleukins).
  • Altered expression of genes involved in cell adhesion and signaling.

    • Conclusions:

    • Aortic dissection exhibits complex molecular alterations.
    • Down-regulation of structural genes and up-regulation of inflammatory genes suggest pre-existing aortic wall weakness.
    • Gene expression patterns indicate insufficient aortic wall remodeling as a potential cause.