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TGF-beta1 gene polymorphisms in periodontal diseases
Gül Atilla1, Gülnur Emingil, Timur Köse
1Department of Periodontology, School of Dentistry, Ege University, Bornova-35100, Izmir, Turkey. gulatilla@yahoo.com <gulatilla@yahoo.com>
Clinical Biochemistry
|July 11, 2006
Summary
The TGF-beta1 (+915C) gene variant may be linked to chronic periodontitis in Turkish individuals. This genetic polymorphism influences transforming growth factor-beta1 (TGF-beta1) activity, a factor in inflammatory diseases.
Area of Science:
- Genetics
- Periodontology
- Immunology
Background:
- Transforming growth factor-beta1 (TGF-beta1) gene polymorphisms affect gene activity and TGF-beta1 levels.
- TGF-beta1 gene variations are linked to inflammatory disease susceptibility.
Purpose of the Study:
- To investigate TGF-beta1 gene polymorphisms in a Turkish population.
- To determine the association between TGF-beta1 genotypes and periodontal disease parameters.
Main Methods:
- Genomic DNA was analyzed from 134 subjects (51 chronic periodontitis, 43 aggressive periodontitis, 40 controls).
- Three TGF-beta1 polymorphisms (+915G/C, Thr263Ile, 713/8delC) were identified using PCR-RFLP and MS-PCR.
- Clinical parameters included probing pocket depth (PPD), clinical attachment loss (CAL), plaque index, and bleeding on probing.
Main Results:
- A significant association was found between the TGF-beta1 +915C genotype and chronic periodontitis (OR: 2.46, p=0.047).
- No significant differences in +915C genotype were observed between aggressive periodontitis and controls.
- The +915C genotype in chronic periodontitis patients correlated with increased PPD and CAL.
Conclusions:
- The TGF-beta1 (+915C) allele may be associated with the risk of developing chronic periodontitis in the Turkish population.
- Further research is warranted to elucidate the role of TGF-beta1 in periodontal disease pathogenesis.
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