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Analysing the developing brain transcriptome with the GenePaint platform.

Gonzalo Alvarez-Bolado¹, Gregor Eichele

¹Max Planck Institute of Biophysical Chemistry, Am Fassberg 11, 37077 Göttingen, Germany.

The Journal of Physiology

|July 11, 2006

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Creating detailed gene expression atlases of the mammalian brain requires robotics and computational tools. These neuroanatomical atlases aid in understanding brain function in normal and modified states.

Area of Science:

Neuroscience
Bioinformatics
Computational Biology

Background:

Gene and protein signaling cascades are complex.
The mammalian brain exhibits intricate neuroanatomical structures.

Purpose of the Study:

To outline technical methods for integrating gene/protein signaling complexity with brain structure.
To highlight the utility of gene expression/neuroanatomical atlases as hypothesis-generating tools.

Main Methods:

Utilizing robotics for image registration.
Developing novel computational tools for annotating and quantifying gene expression.
Creating web-accessible, data-rich gene expression/neuroanatomical atlases.

Main Results:

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Gene expression/neuroanatomical atlases can contain substantial information for investigating brain function.

These atlases are valuable for studying normal brains and those with genetic modifications.

Conclusions:

Robotics and advanced computational tools are essential for building comprehensive brain atlases.
Web accessibility and data mining capabilities are crucial for the utility of these neuroanatomical resources.