Related Experiment Video
Updated: Jul 8, 2026

Drug-Induced Sleep Endoscopy (DISE) with Target Controlled Infusion (TCI) and Bispectral Analysis in Obstructive Sleep Apnea
Published on: December 6, 2016
Upper airway obstruction during nasal intermittent positive-pressure hyperventilation in sleep
P Delguste1, G Aubert-Tulkens, D O Rodenstein
1Rehabilitation Unit, Cliniques Universitaires Saint-Luc, Université Catholique de Louvain, Brussels, Belgium.
Abstract:
Episodes of apnoea for up to 1 min were observed in association with hypocapnia caused by passive nasal intermittent positive-pressure mechanical hyperventilation in 3 of 4 patients during sleep. Apnoea seemed to be caused by complete upper airways obstruction; we suggest that this finding was caused by active glottic closure. Avoidance of excessive hypocapnia during positive-pressure ventilation might help to avoid central-nervous-system mediated apnoeic episodes.
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