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Updated: Aug 7, 2026

Genome-Wide Analysis of DNA Methylation in Gastrointestinal Cancer
07:50

Genome-Wide Analysis of DNA Methylation in Gastrointestinal Cancer

Published on: September 18, 2020

Aberrant methylation of the CHFR gene in digestive tract cancer

Yuki Morioka1, Kenji Hibi, Mitsuru Sakai

  • 1Gastroenterological Surgery, Nagoya University Graduate School of Medicine, Nagoya 466-8560, Japan.

Anticancer Research
|July 11, 2006
PubMed
Abstract

Insights

Aberrant methylation of the CHFR gene is common in esophageal and gastric cancers. This gene methylation occurs across all clinical stages, suggesting it may be an early event in cancer development.

Area of Science:

  • Oncology
  • Molecular Biology
  • Cancer Genetics

Background:

  • Aberrant methylation of the CHFR gene is linked to gene silencing in various cancers.
  • The CHFR gene's methylation status was investigated in esophageal and gastric carcinomas.

Purpose of the Study:

  • To examine the methylation status of the CHFR gene in primary esophageal and gastric cancers.
  • To correlate CHFR gene methylation with clinicopathological findings.

Main Methods:

  • CHFR promoter methylation and mRNA expression analyzed in cancer cell lines.
  • CHFR gene methylation assessed in 38 esophageal and 53 gastric cancer samples.
  • Correlation analysis between CHFR methylation and clinicopathological data performed.

Main Results:

  • CHFR gene aberrant methylation detected in 24% of esophageal and 30% of gastric cancers.
  • Female esophageal cancers showed significantly higher methylation rates than male cancers (p = 0.0404).
  • Abnormal CHFR methylation was observed across all clinical stages for both cancer types.

Conclusions:

  • Frequent aberrant methylation of the CHFR gene observed in esophageal and gastric cancers.
  • CHFR gene methylation occurs at all clinical stages, indicating potential early-stage involvement.
  • CHFR methylation may serve as an early biomarker for esophageal and gastric cancers.

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