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[Age related spirometric changes in diabetic patients].

Alma Rosa Ortíz-Aguirre1, Mario H Vargas, Alfredo Torres-Cruz

  • 1Hospital General Regional No 72, Instituto Mexicano del Seguro Social.

Revista De Investigacion Clinica; Organo Del Hospital De Enfermedades De La Nutricion
|July 11, 2006
PubMed
Summary

Diabetes mellitus (DM) is associated with lower lung function, specifically reduced forced vital capacity (FVC) and forced expiratory volume in one second (FEV1). However, aging affects lung function decline similarly in diabetic and non-diabetic individuals.

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Area of Science:

  • Pulmonary Medicine
  • Diabetology
  • Gerontology

Context:

  • Aging leads to a natural decline in pulmonary function, including lung volumes and expiratory flows.
  • Previous research suggests this decline may be more pronounced in individuals with diabetes mellitus (DM).

Purpose:

  • To investigate whether type-2 diabetes mellitus accelerates the age-related decline in pulmonary function.
  • To compare spirometric parameters between type-2 DM patients and a non-diabetic control group.

Summary:

  • A spirometric study included 144 type-2 DM patients and 139 controls. Diabetic patients exhibited significantly lower forced vital capacity (FVC) and forced expiratory volume in one second (FEV1).
  • Multiple regression confirmed age and DM as predictors of reduced pulmonary function, independent of smoking and BMI.

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  • However, analysis of covariance revealed no significant difference in the rate of pulmonary function decline with age between the two groups.

    • Impact:

    • Diabetic individuals present with diminished FVC and FEV1 compared to non-diabetics.
    • Despite lower baseline values, the aging process impacts pulmonary function decline at a similar rate in both diabetic and non-diabetic populations.
    • This finding highlights the importance of monitoring lung health in diabetic patients while indicating that diabetes itself does not alter the trajectory of age-related pulmonary decline.