[Hyperinsulinemia and insulin-resistance in climacteric women with metabolic syndrome]

The purpose of the study was to evaluate the peculiarities of carbohydrate and lipid dysmetabolism in climacteric women with metabolic syndrome (MS). The subjects of this case-control study were 124 women. The main group consisted of 62 women with MS according to A TP III classification; the control group included 62 women without MS. Anthropometric parameters, blood levels of glucose and immunoreactive insulin, and lipid exchange indices were measured. Thirty-three patients in the main group were obese, and 12 had an excessive body weight; in the control group these conditions were found in 6 and 23 patients, respectively. Patients in the main group developed insulin resistance (IR) significantly more often than the controls did (33 and 15 cases, respectively); the frequency of arterial hypertension, differed significantly between the groups, too. High incidence of IR and carbohydrate dysmetabolism in climacteric women suffering from MS is associated with lipid exchange disturbances, the latter being an independent risk factor of coronary heart disease.