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'Indolent' Waldenstrom's macroglobulinemia and a cerebrospinal fluid protein level of 16 g/L

Laurent Garderet1, Jean Luc Baudel, Pascale Cervera

  • 1Department of Hematology, Hôpital Saint Antoine, Paris, France. laurent.garderet@sat.aphp.fr

European Journal of Haematology
|July 11, 2006
PubMed

Insights

Waldenstrom's macroglobulinemia can cause neurological issues, rarely involving the central nervous system (CNS) as Bing Neel Syndrome. This case highlights significant CNS involvement despite seemingly indolent systemic disease.

Area of Science:

  • Neurology
  • Hematology
  • Oncology

Background:

  • Waldenstrom's macroglobulinemia (WM) is a rare lymphoproliferative disorder.
  • Neurological manifestations are uncommon in WM.
  • Central nervous system (CNS) involvement, known as Bing Neel Syndrome (BNS), is exceptionally rare.

Observation:

  • This report details a patient diagnosed with WM.
  • The patient presented with significant neurological symptoms.
  • The systemic WM was characterized as 'indolent' or slow-growing.

Findings:

  • Despite an indolent systemic presentation, the patient exhibited substantial CNS involvement.
  • This case underscores the potential for severe neurological complications in WM.
  • The findings emphasize the importance of considering BNS in WM patients with neurological signs.

Implications:

  • This case expands the understanding of WM's clinical spectrum.
  • It highlights the diagnostic challenge of BNS, especially with indolent systemic disease.
  • Early recognition and management of CNS involvement are crucial for patient outcomes.

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