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Updated: Aug 7, 2026
07:30
Transcanalicular Diode Laser-assisted Dacryocystorhinostomy for the Treatment of Primary Acquired Nasolacrimal Duct Obstruction
Published on: October 13, 2017
Dacryocystorhinostomy without intubation with intraoperative mitomycin-C
Azizur Rahman1, Shahnawaz Channa, Jawaid Hassan Niazi
1Isra Postgraduate Institute of Ophthalmology, Al-Ibrahim Eye Hospital, Malir City, Karachi. drgeja@hotmail.com
Summary
Intraoperative Mitomycin-C in dacryocystorhinostomy (DCR) surgery significantly improves success rates. This safe and effective method offers a high success rate for DCR procedures.
Area of Science:
- Ophthalmology
- Surgical Innovation
Background:
- Dacryocystorhinostomy (DCR) is a surgical procedure to restore tear drainage.
- Mitomycin-C is an antimetabolite with potential antifibrotic properties.
Purpose of the Study:
- To evaluate the efficacy and safety of intraoperative Mitomycin-C in external DCR surgery.
- To determine the success rate and complication profile of this surgical adjunct.
Main Methods:
- A quasi-experimental study involving 90 patients undergoing external DCR.
- Intraoperative Mitomycin-C (0.2 mg/ml) applied to flaps and osteotomy site for 10 minutes.
- No silicone tube intubation used; patients followed for 6 months.
Main Results:
- A high success rate of 97.77% (p < 0.001) was observed.
- Only 2 out of 90 patients experienced persistent epiphora.
- The primary complication was manageable nasal bleeding.
Conclusions:
- Intraoperative Mitomycin-C is a safe, effective, and cost-efficient adjunct for external DCR.
- It significantly enhances the success rate of DCR surgery.
- The procedure demonstrates a favorable safety profile.
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