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Sublingual vs. vaginal misoprostol for induction of labor
F E L Feitosa1, Z S Sampaio, C A Alencar
1Maternidade-Escola, Universidade Federal do Ceará, Fortaleza, State of Ceará, Brazil. edsonlucena@secrel.com.br
Objective:
To compare sublingual with vaginal misoprostol for the induction of labor.
Methods:
This double-blind clinical trial randomized 150 women to receive every 6 h 25 mug of sublingual misoprostol and vaginal placebo or 25 mug of vaginal misoprostol and sublingual placebo. Maternal and neonatal outcomes were analyzed and risk ratios (RRs) with 95% confidence intervals (CIs) calculated. The significance level was 5%.
Results:
Vaginal delivery rates were 57% in the sublingual group and 69% in the vaginal group (RR, 0.8; 95% CI, 0.6-1.1). There were 11 cases of fetal distress in the sublingual group and 4 cases in the vaginal group (RR, 2.7; 95% CI, 0.9-8.2). There were no significant differences in the number of doses needed, interval between first dose and delivery, incidence of contractility disturbances, or neonatal results.
Conclusion:
The administration of misoprostol 25 mug by the sublingual route was neither more effective nor safer than the same dose administered vaginally.
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