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Related Experiment Videos

Preparing and evaluating delivery systems for proteins.

L Jorgensen1, E H Moeller, M van de Weert

  • 1The Danish University of Pharmaceutical Sciences, Universitetsparken 2, DK-2100 Copenhagen O, Denmark. lej@dfuni.dk <lej@dfuni.dk>

European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences
|July 11, 2006
PubMed
Summary

Developing parenteral protein drug delivery systems is challenging due to protein complexity. This review discusses particulate systems, highlighting water-in-oil emulsions as a key formulation challenge for maintaining protein structure and activity.

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Area of Science:

  • Pharmaceutical Sciences
  • Biotechnology
  • Drug Delivery

Background:

  • Proteins are complex molecules posing significant challenges for drug delivery system development.
  • Maintaining protein native structure and activity is critical for formulation success during preparation, delivery, shipping, and storage.

Purpose of the Study:

  • To review and discuss particulate drug delivery systems for parenteral protein administration.
  • To highlight the challenges associated with incorporating proteins into these delivery systems.

Main Methods:

  • Literature review of particulate drug delivery systems for parenteral protein delivery.
  • Discussion of formulation challenges, using water-in-oil emulsions as a specific example.

Main Results:

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  • Particulate systems offer potential for parenteral protein delivery.
  • Incorporating proteins into particulate systems, such as water-in-oil emulsions, presents significant formulation hurdles.

Conclusions:

  • Effective drug delivery systems are essential for successful protein-based therapeutics.
  • Further research and development are needed to overcome the challenges in formulating stable and active protein delivery systems.