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Published on: December 18, 2016
Thalamic lesion and epilepsy with generalized seizures, ESES and spike-wave paroxysms--report of three cases
Anna Kelemen1, Péter Barsi, Zsuzsanna Gyorsok
1National Institute of Psychiatry and Neurology, Huvösvölgyi út 116, 1021 Budapest, Hungary. kelemen@opni.hu
Abstract:
We report three patients, who have thalamic lesion and secondary generalized epilepsy with generalized spike wave pattern. The first two patients have unilateral perinatal lesion, one with generalized tonic-clonic seizures on awakening the other with Landau-Kleffner-like syndrome. During the course of the disease both children developed electrical status epilepticus in slow wave sleep (ESES). The third patient has a dominantly unilateral thalamic tumor and epilepsy that mimics juvenile myoclonic epilepsy. All the patients have a lesion located in the inferior-medial-posterior part of the thalamus. The role of some thalamic and subthalamic nuclei in the generalized spike-wave electrical pattern patophysiology is discussed, with emphasis on the possible role of the inhibitory system from the zona incerta.
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