Jove
Visualize
Contact Us

Related Experiment Videos

Biomimetic implant coatings.

E Eisenbarth1, D Velten, J Breme

  • 1Hamburg University of Technology, Department of Biomechanics, Hamburg, Germany. eva.eisenbarth@tuhh.de

Biomolecular Engineering
|July 11, 2006
PubMed
Summary

Nanoscale surface structures on niobium oxide coatings significantly impact osteoblast behavior. An intermediate roughness (Ra=15 nm) optimized cell adhesion and spreading on titanium implants.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Technical strategies to improve tissue engineering of cartilage-carrier-constructs.

Advances in biochemical engineering/biotechnology·2009
Same author

Nanostructured niobium oxide coatings influence osteoblast adhesion.

Journal of biomedical materials research. Part A·2006
Same author

[Corrosion behaviour, metal release and biocompatibility of implant materials coated by TiO2-sol gel chemistry].

Biomedizinische Technik. Biomedical engineering·2005
Same author

Biocompatible Nb2O5 thin films prepared by means of the sol-gel process.

Journal of materials science. Materials in medicine·2004
Same author

Biocompatibility of beta-stabilizing elements of titanium alloys.

Biomaterials·2004
Same author

[High incidence of total hip arthroplasty aseptic loosening with ion-coated titanium femoral heads].

Revue de chirurgie orthopedique et reparatrice de l'appareil moteur·2004
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Area of Science:

  • Biomaterials Science
  • Tissue Engineering
  • Cell Biology

Background:

  • Aging populations increase demand for advanced biomaterials and tissue engineering.
  • Nanoscale surface topography of biomaterials critically influences cellular responses and implant integration.
  • Surface structures are key to controlling biological interactions with implants.

Purpose of the Study:

  • Investigate the impact of nanoscopic surface structures on osteoblast interactions.
  • Determine how niobium oxide coatings influence collagen I production and cell adhesion.
  • Optimize biomaterial surface topography for enhanced cellular responses.

Main Methods:

  • Sol-gel process used for niobium oxide coatings on titanium slices (cp-Ti grade 2).
  • Surface structure adjusted via annealing temperatures (450, 550, 700°C) yielding Ra values of 7, 15, and 40 nm.
  • Characterization using AFM, DTA/TG, diffractometry, and white light interferometry; cell responses assessed for adhesion, migration, spreading, and collagen I synthesis.

Main Results:

  • Smooth surfaces (Ra=7 nm) promoted fastest cell anchorage and migration.
  • Intermediate roughness (Ra=15 nm) resulted in the highest cell adhesion.
  • Roughest surfaces (Ra=40 nm) hindered cell migration and spreading.

Conclusions:

  • Biomaterial surface topography at the nanoscale plays a crucial role in osteoblast behavior.
  • An intermediate surface roughness of Ra=15 nm on niobium oxide coatings enhances osteoblast adhesion and spreading.
  • Optimized nanostructure of biomaterial surfaces can improve implant-biological system interactions.

Related Experiment Videos