A duplicated nitrotienyl derivative with antimycobacterial activity: synthesis, X-ray crystallography, biological and
D G Rando1, A C Doriguetto, C H Tomich de Paula da Silva
1Faculdade de Ciências Farmacêuticas, Universidade de São Paulo - Av. Prof. Lineu Prestes, 580, CEP 05508-900, São Paulo, SP, Brazil.
Abstract:
A duplicated nitrotienyl derivative was obtained as a by-product from the synthesis of a proposed molecular hybrid of a nitrotienyl derivative and isoniazid with an expected dual antimycobacteria mechanism. The structure was shown to be the 5,5'-dinitro-2-(2,3-diaza-4-(2'-tienyl)buta-1,3-dienyl)tiophene by X-ray crystallography. The minimal inhibitory concentration (MIC) determination of this compound proved to be promising against Mycobacterium pathogenic strains such as M. avium and M. kansasii, although it had a high level of mutagenicity, as observed in mutagenic activity tests.
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