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TEL/ETV6 induces apoptosis in 32D cells through p53-dependent pathways

Tetsuya Yamagata1, Kazuhiro Maki, Kazuo Waga

  • 1Department of Hematology, Dokkyo Medical University School of Medicine, Tochigi 321-0293, Japan.

Biochemical and Biophysical Research Communications
|July 11, 2006
PubMed
Summary

TEL transcription factor overexpression suppresses myeloid cell proliferation and induces apoptosis by activating the p53 pathway. This suggests a tumor suppressive role for TEL in myelopoiesis.

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