Related Experiment Video
Updated: Aug 7, 2026

Granulocyte-dependent Autoantibody-induced Skin Blistering
Published on: October 12, 2012
[Pathophysiology of Behcet's disease]
Z Amoura1, M Guillaume, S Caillat-Zucman
1Centre national de référence maladies rares, service de médecine interne, hôpital Pitié-Salpêtrière, 47-83, boulevard de l'Hôpital, 75013 Paris, France. zahir.amoura@psl.aphp.fr
Subject:
Pathophysiology of Behçet's disease (BD) is complex. Recent experimental data shed new light on the mechanisms leading to organ lesions.
Main Issues:
Neutrophils and cytotoxic lymphocytes are now recognized as key effector cells in BD. Genetic susceptibility, environmental factors (virus and/or bacterial infections), inflammatory response abnormalities (heat shock proteins, dysregulated NO production) and abnormal immune response play also a major role in BD pathogeny.
Perspectives:
Better understanding of the BD pathophysiology will allow the development of new therapies more specific of BD.
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