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Fat elimination in acute renal failure.
W Druml1, K Widhalm, A Laggner
1Department of Medicine and Department of Paediatrics, University of Vienna, A-1090, Vienna, Austria.
Clinical Nutrition (Edinburgh, Scotland)
|July 1, 1982
Summary
Patients with acute renal failure show impaired lipid metabolism and fat elimination. Fat removal is significantly slower, with prolonged half-life, indicating compromised clearance in these individuals.
Area of Science:
- Nephrology
- Clinical Biochemistry
- Metabolic Research
Background:
- Acute renal failure (ARF) can significantly impact metabolic processes.
- Understanding lipid metabolism disturbances is crucial for managing ARF patients.
Purpose of the Study:
- To investigate lipid metabolism and the elimination of parenterally administered fat in patients with ARF.
- To assess triglyceride and cholesterol levels, lipoprotein composition, and fat elimination rates.
Main Methods:
- Studied 15 patients with ARF.
- Measured serum triglyceride and cholesterol levels.
- Assessed fractional removal rate of triglycerides (K2) using an intravenous fat tolerance test.
Main Results:
- Elevated mean triglyceride levels (2.56 +/- 1.43 mmol/l) and reduced mean cholesterol levels (3.32 +/- 0.66 mmol/l).
- 47% of patients exhibited type IV hyperlipoproteinaemia.
- Reduced fractional removal rate of triglycerides (K2) to 2.44 +/- 1.56 %/min and a prolonged elimination half-life of 28.4 min.
- Elevated VLDL and LDL triglyceride content; reduced HDL and LDL cholesterol concentration.
Conclusions:
- Patients with ARF exhibit impaired lipid metabolism and significantly reduced parenteral fat elimination.
- The study identified specific alterations in lipoprotein composition and delayed triglyceride clearance.
- No correlation found between fat elimination impairment and residual renal function or specific lipid parameters.