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Endogenous glucose production after stomach resection.
H P Sauerwein1, R P Michels, V Cejka
1Department of Internal Medicine, Academic Medical Centre, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands.
Clinical Nutrition (Edinburgh, Scotland)
|December 1, 1982
Summary
Post-stomach resection, glucose requirements were assessed. Minimum glucose infusion should match endogenous glucose production (180g/70kg/day) to ensure adequate metabolic support after surgery.
Area of Science:
- Metabolic Medicine
- Surgical Nutrition
- Endocrinology
Background:
- Gastric surgery, such as stomach resection, significantly alters post-operative metabolic demands.
- Accurate assessment of glucose requirements is crucial for effective patient recovery and nutritional support following major abdominal surgery.
Purpose of the Study:
- To quantify endogenous glucose production (EGP) in patients post-stomach resection.
- To establish optimal glucose infusion rates for patients recovering from elective gastric surgery.
Main Methods:
- Eight patients undergoing stomach resection were studied.
- Glucose turnover was measured using 2-3H-glucose infusion, with EGP calculated as total glucose turnover minus infusion rate.
- Patients received either low (2.1-2.9 g/kg/day) or high (6.2-6.9 g/kg/day) glucose infusions.
Main Results:
- Endogenous glucose production remained consistent across both low and high glucose infusion groups.
- Measured EGP rates were 0.010 +/- 0.002 mmol/kg/min (low glucose) and 0.009 +/- 0.002 mmol/kg/min (high glucose).
Conclusions:
- A minimum daily glucose administration equivalent to endogenous production (approximately 180g for a 70kg individual) is recommended post-stomach resection.
- This finding provides a basis for tailored nutritional strategies in surgical patients with altered gastric anatomy.