Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Insulin and trauma: some thoughts.

G F Cahill1

  • 1Howard Hughes Medical Institute, 398 Brookline Avenue, Boston, Massachusetts 02215, USA.

Clinical Nutrition (Edinburgh, Scotland)
|March 1, 1984
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Some comments on changes in body composition.

Canadian Medical Association journal·2010
Same author

The treatment of cancer of the bladder by radium needles.

The American journal of roentgenology and radium therapy·2010
Same author

Ketone bodies, potential therapeutic uses.

IUBMB life·2001
Same author

Memorial. Sven Martin Gundersen 1904-1998.

Transactions of the American Clinical and Climatological Association·2001
Same author

Survival in starvation.

The American journal of clinical nutrition·1998
Same author

Howard Hughes Medical Institute and its role in genomic activities.

Genomics·1989
Same journal

Dietary modulation of metabo-proteomic reprogramming by the EAT-lancet diet attenuates colorectal cancer risk.

Clinical nutrition (Edinburgh, Scotland)·2026
Same journal

Effects of early postoperative synbiotic supplementation on gastrointestinal outcomes after sleeve gastrectomy: A randomized controlled trial.

Clinical nutrition (Edinburgh, Scotland)·2026
Same journal

Association of preoperative chyme reinfusion via percutaneous endoscopic colostomy with post-reversal Fluid independence in short bowel syndrome patients with an end jejunostomy and an intact but defunctionalized colon.

Clinical nutrition (Edinburgh, Scotland)·2026
Same journal

Intradialytic nutritional intake and adherence perspective of a national and continuous meal model in a large hemodialysis patient cohort.

Clinical nutrition (Edinburgh, Scotland)·2026
Same journal

Nutritional screening within the GLIM procedure-Part 2: Operationalization of the concept risk of malnutrition using a modified Delphi procedure.

Clinical nutrition (Edinburgh, Scotland)·2026
Same journal

Nutritional screening within the GLIM procedure-Part 1: Development of a conceptual definition of risk of malnutrition using a modified Delphi procedure.

Clinical nutrition (Edinburgh, Scotland)·2026
See all related articles

Trauma and sepsis cause muscle protein breakdown, leading to a negative nitrogen balance. Interleukins, while aiding tissue repair, paradoxically increase muscle catabolism, a problem exacerbated by modern nutritional support.

Area of Science:

  • Biochemistry
  • Physiology
  • Immunology

Background:

  • Trauma and sepsis induce a negative nitrogen balance primarily through muscle protein breakdown.
  • This catabolic state is mediated by lymphokines (interleukins) that counteract insulin's anabolic effects on muscle.
  • Interleukins also enhance immune and reparative cell function, promoting tissue repair and defense.

Purpose of the Study:

  • To explain the hormonal mechanisms behind muscle protein breakdown during trauma and sepsis.
  • To elucidate the dual role of interleukins in catabolism and anabolism.
  • To address the implications of parenteral nutrition in the context of these metabolic changes.

Main Methods:

  • Review of existing literature on trauma, sepsis, nitrogen balance, and hormonal signaling.

Related Experiment Videos

  • Analysis of the effects of lymphokines (interleukins) and insulin on muscle and immune cells.
  • Examination of the metabolic consequences of parenteral alimentation.

    • Main Results:

    • Interleukins negate insulin's anabolic effect on skeletal muscle, leading to net catabolism and nitrogen loss.
    • Interleukins augment insulin's anabolic effect on immune and reparative cells, enhancing tissue repair and immune defense.
    • Parenteral nutrition can supply glucose and amino acids, potentially bypassing the need for muscle protein catabolism.

    Conclusions:

    • The body's response to trauma/sepsis prioritizes immune function over muscle preservation.
    • Interleukins play a critical role in this adaptive but detrimental metabolic shift.
    • Parenteral nutrition strategies must consider these complex hormonal interactions to optimize patient recovery.