Related Experiment Video
Updated: Aug 7, 2026

Intracoronary Acetylcholine Provocation Testing for Assessment of Coronary Vasomotor Disorders
Published on: August 18, 2016
Widened coronary arteries in a feverish child
H Rogier van Doorn1, Shirley M Lo-A-Njoe, Jaap Ottenkamp
1Department of Medical Microbiology, Academic Medical Center, University of Amsterdam, Room L1-245, P. O. BOX 22660, 1100DD Amsterdam, The Netherlands. H.R.vanDoorn@amc.nl.
Abstract:
A 3-year-old girl with fever of unknown origin after a visit to Surinam was seen at our hospital. Signs and symptoms were indicative of either Kawasaki syndrome or an acute viral or (atypical) bacterial illness. No cardiac abnormalities were noted at echocardiography. She was treated with intravenous immunoglobulin and clarithromycin and made a quick recovery. Serologically, the diagnosis of murine typhus was made; a flea-borne rickettsiosis caused by Rickettsia typhi. A follow-up echocardiography 1 week later showed a dilated left coronary artery, which was normal again 4 weeks later. We suggest that this phenomenon was a manifestation of rickettsial vasculitis.
Related Concept Videos
Coronary Artery Disease III: Clinical Manifestations
Coronary Artery Disease II: Pathophysiology
Coronary Artery Disease I: Introduction
Imaging Studies for Cardiovascular System III: X-Ray
Definition and Purpose
An X-ray, or radiograph, is a non-invasive method that uses ionizing radiation to take images of internal structures. It is mainly used in cardiac imaging to examine the heart, lungs, and major blood vessels, aiming to identify abnormalities in the heart's size, shape, and position, such as heart failure, congenital defects, and vascular...
Angina I: Introduction
Coronary Artery Disease IV: Preventive Measures