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Hepatitis A and parvovirus B19 infections in an infant with fulminant hepatic failure

Figen Ozçay1, Y Emre Bikmaz, Oğuz Canan

  • 1Department of Pediatric Gastroenterology, Başkent University, School of Medicine, Ankara, Turkey. fozcay@yahoo.com

The Turkish Journal of Gastroenterology : the Official Journal of Turkish Society of Gastroenterology
|July 11, 2006
PubMed

Insights

Hepatitis A virus can cause severe liver failure. In a liver transplant patient, a Parvovirus B19 superinfection was found alongside anemia, suggesting a role in hepatitis and aplastic anemia.

Area of Science:

  • Hepatology
  • Virology
  • Hematology

Background:

  • Fulminant hepatic failure (FHF) can be caused by various hepatitis viruses (A, B, C, D, E).
  • Parvovirus B19 is a known cause of hepatitis-associated aplastic anemia and acute liver failure.

Observation:

  • A patient with fulminant hepatitis A, referred for liver transplantation, developed anemia.
  • Parvovirus B19 superinfection was identified during the patient's clinical course.

Findings:

  • The co-occurrence of hepatitis A virus and Parvovirus B19 infection in a case of FHF with anemia.
  • Potential dual role of these viruses in causing severe liver injury and pure red cell aplasia.

Implications:

  • This case highlights the importance of considering Parvovirus B19 in patients with hepatitis and anemia.
  • Further research is needed to understand the synergistic or independent roles of hepatitis A and Parvovirus B19 in FHF and aplastic anemia.

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