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[Humoral imunity to pertussis in children with diabetes of type 1]

A A Tarasova, M P Kostinov, E M Zaĭtsev

    Zhurnal Mikrobiologii, Epidemiologii I Immunobiologii
    |July 13, 2006
    PubMed

    Insights

    Humoral immunity to pertussis in children with type 1 diabetes wanes by age 6. Booster vaccinations are recommended for children over 4 to maintain protection against pertussis.

    Area of Science:

    • Immunology
    • Pediatrics
    • Endocrinology

    Background:

    • Children with type 1 diabetes may have altered immune responses.
    • Pertussis (whooping cough) remains a concern, especially in vaccinated populations.
    • Understanding humoral immunity to pertussis in diabetic children is crucial for public health.

    Purpose of the Study:

    • To assess IgG antibody levels to pertussis toxin (PT) in children with type 1 diabetes.
    • To evaluate the effectiveness of pertussis vaccination in this cohort.
    • To identify age-related trends in antibody titers and pertussis incidence.

    Main Methods:

    • Enzyme immunoassay (EIA) was used to quantify IgG antibodies to pertussis toxin (PT) in serum samples.
    • Participant data included vaccination history and age.
    • Statistical analysis, including regressive analysis and coefficient of association, was performed.

    Main Results:

    • 100% of children up to 6 years received a full DPT vaccination course, compared to 53.4% of older children.
    • Pertussis incidence was significantly higher in unvaccinated children (p < 0.001).
    • Antibody titers to PT were generally low to average, decreasing after age 6 in fully immunized children. Higher antibody titers, indicating recent infection, were more prevalent in adolescents over 13.

    Conclusions:

    • Pertussis vaccination is effective in protecting type 1 diabetic children up to age 6.
    • Booster vaccinations are necessary for children over 4 years old to ensure prolonged immunity.
    • Increased pertussis incidence in adolescents highlights the need for updated vaccination strategies.

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