Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Intravenous esmolol in acute aortic dissection.

S K Mohindra¹, G O Udeani

¹Critical Care Unit, South Chicago Community Hospital, IL.

DICP : the Annals of Pharmacotherapy

|July 1, 1991

Summary

Acute aortic dissection requires immediate blood pressure control. An ultrashort-acting beta-blocker, esmolol hydrochloride, offers a safer alternative to long-acting beta-blockers in patients with compromised cardiac function.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Pharmacokinetics of deguelin, a cancer chemopreventive agent in rats.

Cancer chemotherapy and pharmacology·2001

Same author

Pharmacokinetics and tissue distribution of betulinic acid in CD-1 mice.

Biopharmaceutics & drug disposition·2000

Same author

Cancer chemopreventive activity mediated by deguelin, a naturally occurring rotenoid.

Cancer research·1997

Same author

Cancer chemopreventive activity of resveratrol, a natural product derived from grapes.

Science (New York, N.Y.)·1997

Same author

Cisplatin nephrotoxicity in a patient with a single kidney.

The Annals of pharmacotherapy·1996

Same author

Compatibility of oral morphine sulfate solution with enteral feeding products.

The Annals of pharmacotherapy·1994

Area of Science:

Cardiology
Pharmacology

Background:

Acute aortic dissection necessitates aggressive management of blood pressure and myocardial contractility.
Current treatment involves sodium nitroprusside and intravenous propranolol hydrochloride.
Conduction abnormalities can arise from hemorrhage extending to the atrioventricular junctional tissues.

Observation:

Long-acting beta-blockers may cause adverse effects like bradycardia, heart failure, and bronchospasm.
These effects can be detrimental in patients with compromised cardiac function or bronchospastic disease.
A case report details a 64-year-old woman with aortic dissection and compromised cardiac function.

Findings:

The patient was successfully treated with sodium nitroprusside and esmolol hydrochloride.
Esmolol hydrochloride, an ultrashort-acting beta-blocker, was used as a therapeutic agent.
This combination effectively managed the patient's condition.

Implications:

Esmolol hydrochloride presents a potentially safer option for beta-blockade in specific patient populations.
This case highlights the utility of ultrashort-acting beta-blockers in managing acute aortic dissection.
Further research may explore the broader application of esmolol in similar cardiovascular emergencies.

Related Experiment Videos