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Related Experiment Videos

Sclerosis multiplex in gypsies.

B Kálmán1, K Takács, E Gyódi

  • 1National Institute of Haematology and Blood Transfusion, Budapest, Hungary.

Acta Neurologica Scandinavica
|September 1, 1991
PubMed
Summary
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Multiple sclerosis (MS) is rare in Hungarian gypsies, but when it occurs, it presents uniquely. Researchers investigated immunogenetic factors, finding DQw6 linked to MS in Hungarians but absent in healthy gypsies, suggesting complex genetic influences on MS susceptibility.

Area of Science:

  • Immunogenetics
  • Neurology
  • Population Genetics

Background:

  • Multiple sclerosis (MS) exhibits unusual prevalence patterns in specific populations, such as its rarity in Hungarian gypsies despite high human leukocyte antigen (HLA) DR2 frequencies.
  • Clinical presentations of MS in gypsies differ from Central Europeans, resembling Asian phenotypes, indicating potential unique genetic underpinnings.

Purpose of the Study:

  • To investigate the correlation between clinical observations of MS in gypsies and Hungarians and their immunogenetic data.
  • To examine the distribution of human leukocyte antigen (HLA) DQw1 subtypes using Eco RV - DQ beta RFLP in DR2-positive healthy individuals and MS patients from both gypsy and Hungarian populations.

Main Methods:

  • Human leukocyte antigen (HLA) DQw1 subtypes were analyzed using Eco RV - DQ beta RFLP (Restriction Fragment Length Polymorphism).

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  • Genotyping was performed on DR2-positive healthy gypsies and Hungarians, as well as DR2-positive Hungarian and unselected gypsy MS patients.
  • Complement allotypes, specifically C4A Q0, were assessed in both groups.

    • Main Results:

    • The DQw6 allotype was significantly correlated with MS susceptibility in Hungarians.
    • DQw6 was completely absent in healthy DR2-positive gypsies but present in DR2-positive gypsy MS patients.
    • No correlation was found between complement allotypes and MS occurrence in Hungarians. However, a striking elevation of C4A Q0 was observed in gypsy MS patients compared to healthy gypsies.

    Conclusions:

    • The absence of the DR2, DW2, DQw6 haplotype and the presence of C4A Q0 in healthy gypsies may contribute to the low prevalence of MS in this population.
    • While specific HLA haplotypes and complement allotypes appear associated with MS risk, genetic factors beyond these regions likely also influence MS susceptibility in diverse populations.