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A Point-of-Care Method with Integrated Decision Support Tool to Estimate Anemia at Population Level
Published on: January 19, 2024
[Decision tools for selecting industrial sites where a systematic blood lead screening should be implemented]
P Glorennec1, M Ledrans, B Fabres
1Ecole Nationale de la Santé Publique, avenue du Pr.-Léon-Bernard, 35043 Rennes Cedex. philippe.glorennec@ensp.fr
Background:
Children exposure to lead, even at low doses, can induce neurobehavioral and cognitive effects. In France, a consensus conference about lead poisoning in children has recently stated that exposure near an industrial site was a priority for blood lead screening. Selection criteria for industrial sites have therefore to be defined, especially because screening for lead poisoning requires a blood lead sample, that is an invasive procedure.
Methods:
We propose here an operational procedure to select sites where systematic blood lead screenings have to be implemented. It is based on modeling blood lead levels of children aged 1-6 years. This is made by indirect dose estimation from environmental measurements, human exposure parameters and a dose/blood lead level relationship. Decision criteria are based on mean and extreme predicted blood lead level. The procedure is illustrated with a real life smelter case study.
Results:
For the studied smelter, estimated blood lead levels are less than 100 microg(Pb)/l(blood) and therefore do not lead to recommend a systematic blood lead screening.
Conclusions:
Indirect dose estimation associated with blood lead level modeling is a useful tool for selecting where blood lead screenings have to be implemented around industrial sites. Possible improvements of the method are listed.
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