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Immunoexpression of multidrug-resistance protein 2 and cyclooxygenase 2 in medullary thyroid carcinomas

Rosaria Maddalena Ruggeri1, Salvatore Sciacchitano, Enrica Vitarelli

  • 1Sezione di Endocrinologia, Dipartimento Clinico-Sperimentale di Medicina e Farmacologia, Policlinico Universitario, Messina, Italy.

Archives of Pathology & Laboratory Medicine
|July 13, 2006
PubMed
Abstract

Insights

Multidrug-resistance protein 2 (MRP2) and cyclooxygenase 2 (COX2) expression in medullary thyroid carcinoma (MTC) correlates with tumor stage. High MRP2 and low COX2 may predict resistance to chemotherapy in advanced MTC.

Area of Science:

  • Oncology
  • Molecular Biology
  • Biochemistry

Background:

  • Chemoresistance in medullary thyroid carcinoma (MTC) is linked to multidrug-resistance proteins (MRPs).
  • Cyclooxygenase 2 (COX2) upregulates MRP1, but MRP2's role in MTC chemoresistance is unknown.
  • MRP1 is overexpressed in MTC but not linked to doxorubicin/cisplatin resistance, unlike MRP2.

Purpose of the Study:

  • To investigate the expression of MRP2 and COX2 in medullary thyroid carcinoma.
  • To correlate MRP2 and COX2 expression with pTNM staging and clinical stage in MTC.

Main Methods:

  • Immunohistochemical analysis of MRP2 and COX2 expression in 12 MTC primary tumors and 6 lymph node metastases.
  • Correlation of protein expression with pTNM and clinical stage.

Main Results:

  • MRP2 and COX2 were detected in MTC tumors and metastases.
  • MRP2 expression was higher in advanced pTNM stage T4 MTCs and metastases.
  • COX2 expression was higher in earlier stages (T2-T3) and decreased with advanced stage; MRP2 and COX2 showed inverse correlation.

Conclusions:

  • MRP2 and COX2 expression levels correlate with pTNM stage in MTC.
  • Elevated MRP2 and reduced COX2 expression may contribute to chemoresistance in advanced MTC.
  • Assessing MRP2 and COX2 expression patterns could help predict MTC chemosensitivity.

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