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Related Experiment Videos

Fluorescent in situ hybridization and array comparative genomic hybridization: complementary techniques for genomic

Carl Morrison1

  • 1The Pathology Core Facility,Arthur James Cancer Hospital and Richard Solove Research Institute, The Ohio State University Medical School, Columbus 43210, USA. Carl.Morrison@osumc.edu

Archives of Pathology & Laboratory Medicine
|July 13, 2006
PubMed
Summary

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Array comparative genomic hybridization is a new, reproducible DNA-based technology gaining attention. It offers similar genome analysis to fluorescent in situ hybridization, impacting surgical pathology practices.

Area of Science:

  • Molecular biology
  • Genomics
  • Surgical pathology

Background:

  • Array comparative genomic hybridization (aCGH) is a high-throughput molecular technology.
  • aCGH is a DNA-based tool with presumed higher reproducibility than expression arrays.
  • Fluorescent in situ hybridization (FISH) is a recognized accurate and reproducible technique in diagnostic surgical pathology.

Purpose of the Study:

  • To review array comparative genomic hybridization (aCGH).
  • To compare aCGH with fluorescent in situ hybridization (FISH) for genome analysis.
  • To highlight the future impact of aCGH on surgical pathology.

Main Methods:

  • Review of array comparative genomic hybridization technology.
  • Comparison of aCGH with fluorescent in situ hybridization (FISH).

Related Experiment Videos

  • Discussion of genome analysis applications.

    • Main Results:

    • Array comparative genomic hybridization (aCGH) shows significant similarities to fluorescent in situ hybridization (FISH) in genome analysis.
    • aCGH is presented as a potentially more reproducible technique than expression arrays.
    • The understanding of aCGH is crucial for surgical pathologists.

    Conclusions:

    • Array comparative genomic hybridization (aCGH) is a valuable tool for genome analysis.
    • aCGH shares key characteristics with the established FISH technique.
    • Surgical pathologists should prepare for the integration of aCGH into their practice.