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Updated: Aug 7, 2026

Tractable Mammalian Cell Infections with Protozoan-primed Bacteria
Published on: April 2, 2013
Efficient intracellular multiplication of Legionella pneumophila in human monocytes requires functional host cell
Hagen Wieland1, Nicole Hechtel, Marion Faigle
1Department of Livestock Biotechnology, WZW TU Munich, Freising, Germany. hagen.wieland@wzw.tum.de
Abstract:
The infectious agent of Legionnaires' disease, Legionella pneumophila, multiplies intracellularly in a variety of eukaryotic cells. Genistein, a tyrosine kinase inhibitor, has been shown to block intracellular replication of L. pneumophila without harming the infected host cell. The present study has been performed to investigate the underlying mechanism. We demonstrate that inhibition of intracellular bacterial growth by genistein is not mediated by its protein tyrosine kinase-modulating effect but by inhibition of L-type calcium channels of the infected host cell.
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