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Non-random association between DNA markers and Huntington disease locus in the Italian population
A Novelletto1, P Mandich, E Bellone
1Dipartimento di Biologia, Università Tor Vergata, Roma, Italy.
American Journal of Medical Genetics
|September 1, 1991
Abstract:
A group of Huntington disease (HD) families of Italian ancestry was analyzed for 11 RFLPs from genetic loci mapped in 4p16 and genetically linked to the HD gene. We found a statistically significant difference of allele distributions in HD vs normal chromosomes for loci D4S10, D4S127, and D4S43. This observation increases the number of loci in linkage disequilibrium with HD. However, the amount of disequilibrium does not allow either a finer localization of the HD gene or a substantial improvement in risk calculations.