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Updated: Aug 7, 2026

Glucose Uptake Measurement and Response to Insulin Stimulation in In Vitro Cultured Human Primary Myotubes
Published on: June 25, 2017
Inhibition of muscular glucose uptake by lipid infusion in man
K Rett1, M Wicklmayr, G Dietze
1IIIrd. Medical Department Krankenhaus-Schwabing and Forscher-gruppe Diabetes D-8000 Munich 40 Germany.
Abstract:
During a high-dose intravenous infusion of a mixed MCT/LCT-lipid emulsion and a conventional LCT-emulsion respectively, muscle substrate metabolism was investigated using the human forearm technique. With both lipid emulsions, a decrease in fractional muscular glucose extraction was seen, leading to significantly reduced muscular glucose uptake rates. An inverse linear relation between arterial tree fatty acids supply and fractional glucose extraction was seen suggesting that a mechanism according to Randle's glucose fatty acid concept is operating in skeletal muscle in man.
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