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Updated: Aug 7, 2026

Monocular Visual Deprivation and Ocular Dominance Plasticity Measurement in the Mouse Primary Visual Cortex
Published on: February 8, 2020
Cytochrome oxidase and neurofilament reactivity in monocularly deprived human primary visual cortex
Kevin R Duffy1, Kathryn M Murphy, Matthew P Frosch
1Department of Psychology, Life Sciences Centre, Dalhousie University, Halifax, Nova Scotia, Canada. kevin.duffy@dal.ca
Abstract:
Previous studies of human primary visual cortex (V1) have demonstrated a significant eye-specific decrease in cytochrome oxidase (CO) staining following monocular enucleation. We have extended these results by examining CO staining and neurofilament labeling in V1 from a patient with long-standing monocular blindness. A pattern of reduced neurofilament reactivity was found to align with pale CO-stained ocular dominance columns. Neurons located within deprived ocular dominance columns were significantly smaller compared with those in nondeprived columns. A spatial analysis of the relationship between CO blobs and ocular dominance columns revealed that both deprived and nondeprived blobs tended to align with the centers of ocular dominance columns.
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