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Axonal polyneuropathy after acute dimethylamine borane intoxication.
Hung-Chou Kuo1, Chin-Chang Huang, Chun-Che Chu
1Department of Neurology, Chang Gung Memorial Hospital and University, Taipei, Taiwan.
Archives of Neurology
|July 13, 2006
Summary
Acute exposure to dimethylamine borane (DMAB) can cause motor-predominant axonal polyneuropathy. This study documents a case of DMAB intoxication and suggests establishing exposure limits.
Area of Science:
- Toxicology
- Neurology
- Occupational Health
Background:
- Dimethylamine borane (DMAB) is increasingly used in semiconductor and electronics manufacturing.
- Understanding the toxicological profile of DMAB is crucial for worker safety.
Observation:
- A chemical factory worker experienced confusion and drowsiness after acute DMAB exposure.
- Cognitive impairments and peripheral neuropathy developed following the exposure.
Findings:
- Nerve conduction studies revealed motor-predominant axonal polyneuropathy.
- Sural and cutaneous nerve biopsies showed axonal degeneration and loss of epidermal nerves.
- Quantitative sensory testing indicated impaired sensation.
Implications:
- DMAB intoxication can lead to significant neurological deficits, including axonal polyneuropathy.
- Establishing a threshold limit value for DMAB exposure is recommended.
- This case highlights the need for safety protocols in industries using DMAB.