Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Neoplastic meningitis.

Marc C Chamberlain1

  • 1Department of Interdisciplinary Oncology, H. Lee Moffitt Cancer Center and Research Institute, University of Southern Florida, Neuro-Oncology Program, Tampa, Florida 33612, USA. chambemc@moffitt.usf.edu

The Neurologist
|July 13, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A multi-institutional phase II trial of bevacizumab for recurrent and refractory meningioma.

Neuro-oncology advances·2022
Same author

"You can observe a lot by just watching" (Yogi Berra).

Neuro-oncology·2021
Same author

Leptomeningeal metastases: how best to assess response.

Neuro-oncology·2020
Same author

Corticosteroid use endpoints in neuro-oncology: Response Assessment in Neuro-Oncology Working Group.

Neuro-oncology·2018
Same author

Leptomeningeal metastasis.

Handbook of clinical neurology·2018
Same author

Immunochemotherapy, the New Standard of Care for Primary CNS Lymphoma: However, Which One?

Journal of clinical oncology : official journal of the American Society of Clinical Oncology·2017

Neoplastic meningitis (NM) affects the entire nervous system, requiring comprehensive staging and treatment across all cerebrospinal fluid (CSF) compartments. While palliative, NM treatments stabilize patients and prevent further neurological decline.

Area of Science:

  • Neuro-oncology
  • Neurology
  • Cancer Metastasis

Background:

  • Neoplastic meningitis (NM) is a frequent complication in neuro-oncology, impacting about 5% of cancer patients.
  • NM affects the entire neuraxis, necessitating a holistic approach to staging and treatment.

Purpose of the Study:

  • To outline the staging and treatment modalities for neoplastic meningitis.
  • To discuss the role of systemic therapy and intra-CSF drug delivery in managing NM.

Main Methods:

  • Central nervous system (CNS) staging involves advanced imaging like CE-CT, MR-Gd, MR-S, CT-M, and CSF flow studies.
  • Treatment includes radiotherapy for localized disease and intra-CSF chemotherapy with agents like methotrexate, cytosine arabinoside, and thio-TEPA.
  • Systemic therapy may complement intra-CSF treatments and potentially reduce the need for chemotherapy.

Related Experiment Videos

Main Results:

  • Comprehensive staging and treatment encompassing all CSF compartments are crucial for NM management.
  • Intra-CSF drug therapy utilizes specific chemotherapeutic agents delivered via intralumbar or intraventricular routes.
  • Concomitant systemic therapy shows potential benefits and may reduce reliance on intra-CSF chemotherapy.

Conclusions:

  • Treatment for NM, though palliative, aims to stabilize patients and prevent further neurological deterioration.
  • The median survival for patients with NM is typically 2 to 6 months.
  • Integrated treatment strategies are essential for managing this complex neurological complication.