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Updated: Aug 7, 2026

A Model to Simulate Clinically Relevant Hypoxia in Humans
Published on: December 22, 2016
Tachypnea and hypocapnia are induced by 'buffeting' in vehicles
David Andrew Green1, Adam Bray, John Foster Golding
1Division of Neuroscience and Psychological Medicine, Imperial College London, Charing Cross Hospital Campus, Hammersmith, London, UK. david.green@imperial.ac.uk
Abstract:
Normal physiological responses to vehicular buffeting were studied during a 5 minute mild 'off road' exposure in a motion simulator. The ride provoked an initial increase in heart rate and blood pressure and a significant hypocapnia of P(ET) CO(2) 34 mm Hg caused by tachypnea, which took 5 minutes to recover. Motion induced hypocapnia could be a source of distress for vulnerable subjects and patients when travelling.
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