Changes of serum cytokine profiles in Korean vivax malarial patients after chemotherapy
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1Department of Tropical and Endemic Parasitic Diseases, National Institute of Health, Seoul, 122-701, South Korea.
Abstract:
Changes of serum cytokines including interferon gamma inducible protein-10 (IP-10) chemokine were analyzed in a total of eight vivax malarial patients before and after chemotherapy by immunostaining for human cytokine antibodies attached to membranes. IP-10 was strongly reactive in the period before chloroquine/primaquine combined chemotherapy and disappeared after chemotherapy in all patients. Therefore, IP-10 chemokine may be of importance in the pathogenesis of vivax malaria and a good marker of a complete cure.
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