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Age-related leukocyte and cytokine patterns in community-acquired bronchopneumonia

Ami Ballin1, Alla Osadchy, Alla Osdachi

  • 1Department of Pediatrics, Wolfson Medical Center, Holon, Israel. ballin@wolfson.health.gov.il

The Israel Medical Association Journal : IMAJ
|July 13, 2006
PubMed

Insights

Community-acquired bronchopneumonia shows higher leukocyte counts in children than adults. Inflammatory cytokine levels were similar, but immune responses appear age-dependent.

Area of Science:

  • Pediatric and adult infectious diseases
  • Immunology
  • Hematology

Background:

  • Community-acquired bronchopneumonia (CABP) often presents with extreme leukocytosis in children, unlike adults.
  • Limited data exists on serum inflammatory cytokine differences between pediatric and adult CABP patients.

Purpose of the Study:

  • To compare leukocyte counts and serum inflammatory cytokine levels in pediatric and adult patients diagnosed with CABP.

Main Methods:

  • Prospective evaluation of pediatric and adult patients admitted for CABP based on clinical and chest X-ray findings.
  • Analysis of complete blood counts and serum concentrations of granulocyte colony-stimulating factor (G-CSF), interleukins (IL-6, IL-8, IL-10), interferon-gamma, tumor necrosis factor, matrix metalloproteinase-9 (MMP-9), and intercellular adhesion molecule-1.

Main Results:

  • Mean leukocyte counts were significantly higher in children (21,018/mm3) than adults (12,628/mm3).
  • Age was inversely correlated with leukocyte and platelet counts in the pediatric group.
  • While overall cytokine levels did not differ significantly, age correlated positively with MMP-9, IL-8, and G-CSF.

Conclusions:

  • The immune response in community-acquired bronchopneumonia exhibits age-dependent characteristics.
  • Leukocyte count differences in CABP between children and adults may be influenced by age-related immune responses.
Abstract

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