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Antral gastrin cell hyperfunction in children. A functional and immunocytochemical report

B Annibale1, M Bonamico, G Rindi

  • 1I Cattedra di Gastroenterologia, Università degli Studi La Sapienza, Rome, Italy.

Gastroenterology
|December 1, 1991
PubMed

Insights

Antral gastrin cell hyperfunction, a rare condition, can cause bleeding or abdominal pain in children. Diagnosis is crucial as it may present without peptic ulcers.

Area of Science:

  • Pediatric Gastroenterology
  • Endocrinology
  • Cell Biology

Background:

  • Antral gastrin cell hyperfunction is a rare endocrine disorder.
  • Its clinical presentation and functional characteristics in children are not well-documented.

Observation:

  • Two pediatric cases presented with melena and abdominal pain, respectively, without peptic ulceration.
  • Elevated basal and postprandial gastrin levels indicated gastrin cell hyperfunction.
  • Acid hypersecretion was confirmed via basal and pentagastrin-stimulated testing.

Findings:

  • Gastrin cell counts were normal, but somatostatin D cell numbers were significantly reduced.
  • These findings confirm the biological impact of sustained hypergastrinemia in affected children.

Implications:

  • Highlights the importance of diagnosing antral gastrin cell hyperfunction in pediatric patients.
  • Undiagnosed cases may lead to severe complications like bleeding or nonspecific abdominal symptoms.

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