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Updated: Jul 30, 2026

Investigating the Effects of Antipsychotics and Schizotypy on the N400 Using Event-Related Potentials and Semantic Categorization
Published on: November 19, 2014
[Zotepine: treatment of schizophrenic patients with predominantly negative symptoms. A double-blind study vs.
C Barnas1, C H Stuppäck, C Miller
1Arbeitsgruppe für Biologische Psychiatrie, Universität Innsbruck Osterreich.
Abstract:
Zotepine, a neuroleptic exercising a 5-HT2-antagonistic effect, was employed in a double-blind study in the treatment of schizophrenic patients with predominantly negative symptoms and was compared to haloperidol. In contrast to the patients treated with haloperidol, significant improvements were seen in the zotepine group during the observation period, according to all assessment scales that were employed. The patients of the zotepine group also developed fewer clinical side effects. The results of the study confirm previous positive impressions gained in earlier open studies with zotepine.
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