Related Experiment Video
Updated: Jul 17, 2026

18:08
Interview: Glycolipid Antigen Presentation by CD1d and the Therapeutic Potential of NKT cell Activation
Published on: December 31, 2007
Structure-based discovery of glycolipids for CD1d-mediated NKT cell activation: tuning the adjuvant versus
Masakazu Fujio1, Douglass Wu, Raquel Garcia-Navarro
1The Scripps Research Institute, La Jolla, California 92037, USA.
Journal of the American Chemical Society
|July 13, 2006
Abstract:
Introduction of an aromatic group into the fatty acyl chain of alpha-GalCer modulates the activity and selectivity of IFN-gamma/IL-4 secretion through CD1d-mediated activation of NKT cells. Compound 14-16 are more potent than alpha-Galcer and biased for IFN-gamma than for IL-4. These new glycolipids may find use as adjuvants or as antimetastatic agents.

