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Adenoid mast cells and their role in the pathogenesis of otitis media with effusion

B Abdullah1, S Hassan, D Sidek

  • 1Department of Otorhinolaryngology-Head and Neck Surgery, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia. baharudin@kb.usm.my

The Journal of Laryngology and Otology
|July 13, 2006
PubMed
Abstract

Insights

Children with otitis media with effusion (OME) have significantly more adenoid mast cells. This suggests that inflammation involving adenoid mast cells may contribute to the development of OME.

Area of Science:

  • Otorhinolaryngology
  • Immunology
  • Pediatrics

Background:

  • Otitis media with effusion (OME) is characterized by middle ear fluid accumulation with an intact tympanic membrane.
  • The link between adenoid inflammation and OME is recognized, but the precise mechanism remains unclear.
  • Adenoid mast cells are investigated for their potential role in OME pathogenesis.

Purpose of the Study:

  • To investigate the distribution and function of adenoid mast cells in the causation of OME.
  • To determine if adenoid mast cell populations differ between children with and without OME.

Main Methods:

  • A prospective study involving 50 children was conducted from June 1999 to September 2001.
  • Adenoid specimens were analyzed for mast cell counts using light microscopy and toluidine blue staining.
  • Patients underwent either adenoidectomy or adenoidectomy with myringotomy and ventilation tube insertion.

Main Results:

  • A statistically significant increase in adenoid mast cell populations was observed in children with OME compared to those without OME (p=0.000).

Conclusions:

  • Elevated adenoid mast cell numbers in OME patients indicate a potential role for inflammation in this condition.
  • Further research into the inflammatory pathways involving adenoid mast cells is warranted for OME management.

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