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Related Experiment Videos

[Capecitabine].

Kensei Yamaguchi1, Tomotaka Shimamura, Masahiro Tada

  • 1Dept. of Gastroenterology, Saitama Cancer Center Hospital.

Gan to Kagaku Ryoho. Cancer & Chemotherapy
|July 13, 2006
PubMed
Summary

Capecitabine offers comparable efficacy and safety to 5-FU/LV for colorectal cancer treatment. This oral fluoropyrimidine shows promise in adjuvant and first-line settings, with manageable side effects like hand-foot syndrome.

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Area of Science:

  • Oncology
  • Pharmacology
  • Clinical Trials

Context:

  • Capecitabine is a widely adopted oral fluoropyrimidine carbamate.
  • It serves as a treatment for metastatic colorectal cancer and adjuvant therapy for resected stage III colon cancer.

Purpose:

  • To evaluate the efficacy and safety of capecitabine compared to bolus 5-fluorouracil/leucovorin (5-FU/LV).
  • To assess capecitabine-based combination regimens in phase II studies.
  • To review capecitabine's performance in Japan since 1994.

Summary:

  • Capecitabine demonstrated comparable efficacy and a favorable safety profile to 5-FU/LV in metastatic and adjuvant colorectal cancer settings.
  • Phase II studies show promising results for capecitabine in combination therapies.
  • A recent Japanese phase II study reported a 35% response rate, 169-day median time to progression, and 617-day median overall survival for first-line metastatic colorectal cancer.

Impact:

  • Capecitabine provides an effective oral alternative to intravenous chemotherapy for colorectal cancer.
  • Management of hand-foot syndrome, a common side effect, is crucial for treatment adherence.
  • The drug's favorable profile supports its continued evaluation and potential for broader clinical adoption.

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