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Polycyclic aromatic hydrocarbons in traditional medicinal preparations
J P Jani1, C V Raiyani, J S Mistry
1Department of Pharmacology, University of Pittsburgh, School of Medicine, PA 15261.
Human & Experimental Toxicology
|September 1, 1991
Summary
Ayurvedic bhasmas were analyzed for polycyclic aromatic hydrocarbons (PAH). All tested preparations contained PAH, with levels varying widely, including significant benzo(a)pyrene concentrations.
Area of Science:
- Ayurvedic medicine
- Analytical chemistry
- Environmental toxicology
Background:
- Ayurvedic bhasmas are traditional Indian mineral-based formulations.
- Concerns exist regarding potential contaminants in herbal and mineral preparations.
- Polycyclic Aromatic Hydrocarbons (PAH) are a group of environmental pollutants with known health risks.
Purpose of the Study:
- To determine the presence and levels of polycyclic aromatic hydrocarbons (PAH) in Ayurvedic bhasmas.
- To quantify specific PAH, including benzo(a)pyrene, in these preparations.
Main Methods:
- Analysis of Ayurvedic medicinal preparations (bhasmas).
- Determination of polycyclic aromatic hydrocarbons (PAH) using analytical techniques.
- Quantification of total PAH and benzo(a)pyrene levels.
Main Results:
- All analyzed Ayurvedic bhasma preparations contained detectable levels of PAH.
- The total PAH content varied significantly across different preparations, ranging from 2.32 to 9.55 ppm.
- Benzo(a)pyrene, a carcinogenic PAH, was detected at concentrations up to 9.7 ppm.
Conclusions:
- Ayurvedic bhasmas can be a source of exposure to polycyclic aromatic hydrocarbons (PAH).
- The variability in PAH levels highlights the need for quality control in the production of Ayurvedic medicines.
- Further research is warranted to assess the health implications of PAH contamination in bhasmas.
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