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Updated: Aug 7, 2026
11:54
Measurement of BK-polyomavirus Non-Coding Control Region Driven Transcriptional Activity Via Flow Cytometry
Published on: July 13, 2019
BK virus and cancer in Uganda
Robert Newton1, Tatiana Ribeiro, Eva Alvarez
1Epidemiology and Genetics Unit, Department of Health Sciences, University of York, Heslington, York, UK. Rob.Newton@egu.york.ac.uk
Summary
This study found lower BK virus antibody levels in Ugandan oral cancer patients and higher levels in prostate cancer patients. These findings suggest a potential link between BK virus antibody titres and specific cancer types.
Area of Science:
- Epidemiology
- Virology
- Oncology
Background:
- BK virus (BKV) is a human polyomavirus with a high seroprevalence globally.
- BKV has been investigated for its potential role in various cancers, though associations remain debated.
- Understanding BKV antibody titres in different cancer populations is crucial for epidemiological research.
Purpose of the Study:
- To investigate the association between BK virus antibody titres and various cancer types in a Ugandan population.
- To explore potential correlations between antibody levels and demographic or lifestyle factors, including HIV status.
Main Methods:
- An epidemiological study involving 821 participants with cancer or benign tumors in Uganda.
- Measurement of anti-BK virus antibody titres using mean optical density.
- Statistical analysis including multivariate analysis of variance to adjust for confounding factors like sex, age, and HIV status.
Main Results:
- A high seropositivity rate (96%) for anti-BK virus antibodies was observed.
- Mean antibody titre was significantly higher in women than men and in HIV-seropositive individuals compared to seronegative individuals.
- A significantly lower mean antibody titre was found in patients with oral cancer (17% lower) and a higher titre in prostate cancer patients (20% higher).
Conclusions:
- BK virus antibody titres show distinct associations with oral and prostate cancer in the Ugandan cohort.
- The observed differences warrant further investigation, acknowledging the small sample sizes for specific cancer types.
- Further research is needed to elucidate the role of BK virus in the pathogenesis of these cancers.
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