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[Psychosexual aspects of intersex syndromes]

H A G Bosinski1

  • 1Sexualmedizinische Forschungs- und Beratungsstelle, Universitätsklinikum Schleswig-Holstein, Campus Kiel, Arnold-Heller-Str. 12, 24105, Kiel. hagbosi@sexmed.uni-kiel.de

Der Urologe. Ausg. A
|July 13, 2006
PubMed

Insights

Ambiguous genitalia, or disorders of somatosexual development, affect 1 in 3,000-5,000 newborns. This review covers etiology, treatment, and outcomes for congenital adrenal hyperplasia and androgen insensitivity syndromes.

Area of Science:

  • Endocrinology
  • Genetics
  • Pediatrics

Context:

  • Disorders of somatosexual development, leading to ambiguous genitalia, affect 1 in 3,000-5,000 newborns.
  • These conditions present complex challenges for parents and healthcare professionals regarding sex assignment, hormonal and surgical interventions, and long-term outcomes.
  • Key syndromes discussed include congenital adrenal hyperplasia (CAH), complete and partial androgen insensitivity (cAIS, pAIS), and pure and mixed gonadal dysgenesis (pGD, mGD).

Purpose:

  • To review the etiology, treatment options, and outcomes related to gender identity and sexual health for specific disorders of sex development.
  • To highlight current discussions on the optimal timing and extent of genital surgery.
  • To introduce a comprehensive procedure addressing the sexual-medical needs of patients, parents, and healthcare providers.

Summary:

  • This paper examines the causes, management strategies, and consequences for gender identity and sexual health in newborns with ambiguous genitalia.
  • It focuses on congenital adrenal hyperplasia (CAH), androgen insensitivity syndromes (AIS), and gonadal dysgenesis (GD).
  • The review emphasizes the ongoing debate surrounding genital surgery and presents a holistic approach to patient care.

Impact:

  • Provides a comprehensive overview of disorders of sex development for clinicians and researchers.
  • Informs clinical decision-making regarding sex assignment, surgical, and hormonal interventions.
  • Aims to improve the psychosexual well-being and fertility outcomes for affected individuals.

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