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Stereotactic Radiosurgery for Gynecologic Cancer
Published on: April 17, 2012
Stereotactic radiosurgery in patients with multiple brain metastases
S D Chang1, E Lee, G T Sakamoto
1Department of Neurosurgery, Stanford University School of Medicine, Stanford, California 94305, USA. sdchang@stanford.edu
Neurosurgical Focus
|July 14, 2006
Summary
Stereotactic radiosurgery effectively treats multiple brain metastases, with 91% showing tumor size reduction or stability. This method offers a low rate of radiation necrosis and minimal need for subsequent surgery in patients with up to four brain lesions.
Area of Science:
- Neurosurgery
- Radiation Oncology
- Oncology
Background:
- Fractionated whole-brain radiation therapy (WBRT) is standard for multiple brain metastases.
- Previous studies indicate stereotactic radiosurgery (SRS) benefits patients with up to four brain metastases.
- This paper reviews SRS experience in treating multiple brain metastases.
Purpose of the Study:
- To review the efficacy and safety of linear accelerator-based stereotactic radiosurgery for multiple brain metastases.
- To evaluate tumor response, complications, and survival in patients treated with SRS.
Main Methods:
- Fifty-three patients with 149 brain metastases underwent SRS.
- Mean radiation dose was 19.6 Gy; mean collimator size was 15.7 mm.
- Tumor response assessed by MRI at 3 months; complications and survival tracked.
Main Results:
- 91% of treated tumors showed decreased size or stabilization.
- Radiation-induced necrosis occurred in 5.4% of tumors.
- Median survival was 9.6 months; 4.7% of tumors required resection.
Conclusions:
- SRS is effective for up to four brain metastases, achieving high tumor control rates.
- SRS demonstrates a low incidence of radiation necrosis.
- Surgical intervention for treated lesions was infrequent in this cohort.
