Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Efficient access to cyclic ureas via Pd-catalyzed cyclization.

Mark McLaughlin1, Michael Palucki, Ian W Davies

  • 1Department of Process Research, Merck Research Laboratories, P.O. Box 2000, Rahway, New Jersey 07065, USA. mark_mclaughlin@merck.com

Organic Letters
|July 14, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Reirradiation treatment effects in the clinic (ReTEC) proposal - proof of concept based on spinal cord dose tolerance for reirradiation with stereotactic body radiotherapy.

Journal of applied clinical medical physics·2026
Same author

A canine <i>PLP1</i> missense variant differentiates oligodendrocyte maturation in connatal and classical Pelizaeus-Merzbacher disease.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

Serum Biomarkers in Atlantic Salmon for Differential Diagnosis of Cardiomyopathy Syndrome and Pancreas Disease: Proteomic Identification of Serum Fibrinogen to Enhance Troponin Immunoassay as Optimal Diagnostic Approach.

Journal of fish diseases·2025
Same author

Urine Neutrophil Gelatinase-Associated Lipocalin in Non-Associative Immune Mediated Hemolytic Anemia: A Prospective Controlled Study in 22 Dogs.

Journal of veterinary internal medicine·2025
Same author

Common lizard primary oviduct cell culture: A model system for the genetic and cellular basis of oviparity and viviparity.

Experimental cell research·2024
Same author

Identification of novel biomarkers of acute phase response in chickens challenged with Escherichia coli lipopolysaccharide endotoxin.

BMC veterinary research·2024

This study presents an efficient method for synthesizing imidazopyridinones and benzoimidazolones. The novel chemistry utilizes readily available materials for rapid access to pharmaceutically relevant heterocyclic compounds.

Area of Science:

  • Organic Chemistry
  • Medicinal Chemistry
  • Synthetic Chemistry

Background:

  • Imidazopyridinones and benzoimidazolones are crucial heterocyclic scaffolds in medicinal chemistry.
  • Developing efficient and regioselective synthetic routes to these compounds is of significant interest.
  • Existing methods may suffer from limited substrate scope, harsh conditions, or low yields.

Purpose of the Study:

  • To develop a novel, efficient, and regioselective method for preparing diverse imidazopyridinones and benzoimidazolones.
  • To utilize readily available and economical starting materials for broad applicability.
  • To provide rapid access to pharmaceutically important heterocyclic compounds.

Main Methods:

  • Reductive alkylation of electron-deficient ortho-haloarylamines.

Related Experiment Videos

  • Treatment of resulting amines with N-chlorosulfonyl isocyanate to form primary ureas.
  • Palladium-catalyzed cyclization of the primary ureas to yield the target heterocycles.

    • Main Results:

    • The developed method provides high overall yields for primary ureas.
    • Palladium-catalyzed urea cyclization proceeds in excellent yields.
    • Structurally diverse imidazopyridinones and benzoimidazolones are prepared efficiently and regioselectively.

    Conclusions:

    • The described chemistry offers a rapid and efficient route to valuable imidazopyridinone and benzoimidazolone derivatives.
    • This method is suitable for the synthesis of pharmaceutically relevant heterocyclic compounds.
    • The use of economical starting materials enhances the practical utility of this synthetic approach.