Related Experiment Video
Updated: Aug 7, 2026

10:35
Multimodal Imaging and Spectroscopy Fiber-bundle Microendoscopy Platform for Non-invasive, In Vivo Tissue Analysis
Published on: October 17, 2016
Homogeneous blue pigmentation in dermatofibroma simulating a blue naevus
Summary
A rare skin lesion initially diagnosed as a blue nevus was confirmed as a dermatofibroma. This case highlights dermatofibroma as an exception to the typical dermoscopic pattern of homogeneous blue pigmentation.
Area of Science:
- Dermatology
- Dermoscopy
- Histopathology
Background:
- Accurate diagnosis of pigmented skin lesions is crucial for patient management.
- Blue nevi and dermatofibromas are common skin conditions with distinct clinical and dermoscopic features.
- Dermoscopy aids in differentiating benign from malignant pigmented lesions.
Observation:
- A pigmented skin lesion presented with features suggestive of a blue nevus on clinical and dermoscopic examination.
- Histopathological examination revealed the lesion to be a dermatofibroma.
- The dermoscopic finding of homogeneous blue pigmentation, typically associated with blue nevi, was observed.
Findings:
- This case demonstrates that dermatofibroma can exhibit homogeneous blue pigmentation on dermoscopy.
- Dermatofibroma should be considered in the differential diagnosis of lesions with this dermoscopic feature.
- The study defines dermatofibroma as a new exception to the rule for 'homogeneous blue pigmentation' in dermoscopy.
Implications:
- Dermoscopic criteria for diagnosing pigmented lesions require continuous refinement.
- Clinicians should be aware of atypical presentations of common skin conditions.
- This finding may impact diagnostic algorithms and improve the accuracy of differentiating blue nevi from dermatofibromas.
Related Concept Videos
Pigmentation
The color of the skin is influenced by a number of pigments, including melanin, carotene, and hemoglobin. Recall that melanin is produced by cells called melanocytes, which are found scattered throughout the stratum basale of the epidermis. The melanin is transferred to the keratinocytes via melanosomes.
Melanin occurs in two primary forms: eumelanin that provides black and brown pigment and pheomelanin that provides red color. Dark-skinned individuals produce more melanin than those with pale...
Melanin occurs in two primary forms: eumelanin that provides black and brown pigment and pheomelanin that provides red color. Dark-skinned individuals produce more melanin than those with pale...
Skin Cancer
Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Changes in Skin Color: Clinical Perspectives
The first thing a clinician sees is the skin, so the examination of the skin should be part of any thorough physical examination. Most skin disorders are relatively benign, but a few, including melanomas, can be fatal if untreated. A couple of the more noticeable disorders, albinism and vitiligo, affect the appearance of the skin and its accessory organs.
Albinism
Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...
Albinism
Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...
