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Evidence for a decrease in sympathetic control of intestinal function in the aged rat.

D M Baker1, S P Watson, R M Santer

  • 1Department of Surgery, Queen's Medical Centre, Nottingham, UK.

Neurobiology of Aging
|July 1, 1991
PubMed
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Aging impairs the ability of isoprenaline to relax rat ileal smooth muscle, indicating reduced sympathetic nerve function in older animals. This age-related decline affects maximal relaxation, not the drug

Area of Science:

  • Pharmacology
  • Gastroenterology
  • Neuroscience

Background:

  • Aging is associated with changes in the gastrointestinal tract.
  • Sympathetic innervation density in the rat small intestine decreases with age.

Purpose of the Study:

  • To compare the effects of carbachol and isoprenaline on rat ileal smooth muscle in young and aged animals.
  • To investigate age-related alterations in smooth muscle contractility and relaxation responses.

Main Methods:

  • Comparison of concentration-response curves for carbachol and isoprenaline in longitudinal ileal smooth muscle from 6- and 24-month-old rats.
  • Assessment of muscle relaxation in response to isoprenaline after pre-contraction with carbachol.

Main Results:

Related Experiment Videos

  • Carbachol's concentration-response curve was similar in both age groups.
  • Isoprenaline's relaxant effect on carbachol-precontracted ileal smooth muscle was significantly reduced in 24-month-old rats (p < 0.02).
  • The reduced isoprenaline response in aged rats was characterized by decreased maximal relaxation, not a rightward shift in the dose-response curve.

Conclusions:

  • Aging leads to a diminished capacity of isoprenaline to relax rat ileal smooth muscle.
  • The observed reduction in relaxation is linked to age-related decreases in sympathetic innervation density.
  • These findings highlight functional consequences of neurodegenerative changes in the aging gut.