Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Chromatin structure and epigenetics.

A S Quina1, M Buschbeck, L Di Croce

  • 1Center for Genomic Regulation, Passeig Maritim 37-49, 08003 Barcelona, Spain.

Biochemical Pharmacology
|July 14, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Publisher Correction: Live-cell three-dimensional single-molecule tracking reveals modulation of enhancer dynamics by NuRD.

Nature structural & molecular biology·2023
Same author

Live-cell three-dimensional single-molecule tracking reveals modulation of enhancer dynamics by NuRD.

Nature structural & molecular biology·2023
Same author

Different methylation signatures at diagnosis in patients with high-risk myelodysplastic syndromes and secondary acute myeloid leukemia predict azacitidine response and longer survival.

Clinical epigenetics·2021
Same author

Anticancer innovative therapy: Highlights from the ninth annual meeting.

Cytokine & growth factor reviews·2019
Same author

p53 regulates the mevalonate pathway in human glioblastoma multiforme.

Cell death & disease·2015
Same author

p53 gene discriminates two ecologically divergent sister species of pine voles.

Heredity·2015

Chromatin structure, the complex of DNA and proteins, regulates gene expression by controlling DNA accessibility. Its molecular mechanisms and epigenetic transmission are crucial in normal and pathological conditions.

Area of Science:

  • Molecular Biology
  • Epigenetics
  • Genetics

Background:

  • Eukaryotic DNA exists as chromatin, a complex of DNA and proteins.
  • The nucleosome, composed of DNA wrapped around histone proteins, is the basic chromatin unit.
  • Chromatin structure modulation is vital for gene expression regulation.

Purpose of the Study:

  • To provide an overview of molecular mechanisms in chromatin regulation.
  • To explain the epigenetic transmission of chromatin states.
  • To cover chromatin regulation in both normal and pathological contexts.

Main Methods:

  • Review of molecular mechanisms
  • Overview of epigenetic transmission
  • Analysis of chromatin structure modulation

Related Experiment Videos

Main Results:

  • Chromatin structure dictates DNA accessibility and regulatory factor recruitment.
  • Alterations in chromatin constituents and covalent modifications impact gene expression.
  • Histone modifications and DNA methylation are key epigenetic regulators.

Conclusions:

  • Chromatin regulation is a dynamic process essential for cellular function.
  • Epigenetic mechanisms ensure the transmission of chromatin states across cell divisions.
  • Dysregulation of chromatin can lead to pathological conditions.