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Measurement of Pulse Propagation Velocity, Distensibility and Strain in an Abdominal Aortic Aneurysm Mouse Model
Published on: February 23, 2020
Non-invasive determination of zero-pressure geometry of arterial aneurysms
M L Raghavan1, Baoshun Ma, Mark F Fillinger
1Department of Biomedical Engineering, University of Iowa, Iowa City, IA, USA. ml-raghavan@uiowa.edu
Abstract:
Arterial aneurysms are in a pre-deformed state in vivo under non-zero pressure. The ability to determine their zero pressure geometry may help in improving accuracy of determination of stress distribution and reverse estimation of material properties from dynamic imaging data. An approximate method to recover the zero pressure geometry of the AAA is proposed. This method is motivated by the observation that the patterns in displacement field for a given AAA are strikingly consistent in an AAA under all physiological pressures. The basic principle is to leverage this observation to iteratively identify the geometry that when subjected to the in vivo pressure, will recover the geometry reconstructed from in vivo imaging. The methodology is demonstrated and validated using patient-specific AAA models.
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This invasive approach involves cannulating a peripheral artery. During each cardiac contraction, pressure generates mechanical motion within the catheter, transmitted through rigid, fluid-filled tubing to a transducer. This transducer converts mechanical motion into electrical signals displayed as waveforms on a monitor. An automatic flushing system prevents blood backflow. Due to the potential risk of unexpected arterial blood loss, this method is primarily used in intensive...
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